![]() At present, the relationship between structural and functional abnormalities of the amygdala and cognitive impairment is still not clear. Therefore, the abnormality of amygdala function may be the basis of SC’s emotional disharmony, social function and cognitive deficits. Other studies suggested that when patients were angry, the activation of neural activities in the amygdala related to executive function increased 。. found that the functional connection between the amygdala and other brain regions in SC was weakened. only proved that the volume of the amygdala in SC patients could predict memory function, but there was no significant reduction in its volume. showed that the volumes of the bilateral amygdala in SC were smaller than that in healthy people. Abnormalities in the structure and function of the amygdala related to emotional expression disorder in SC studies. BLA receives sensory stimuli transmitted from sensory-related cortical regions, thus driving neuronal activity and mediating emotional behavior. In these subregions, BLA, central amygdala (CeA) and medial amygdala (MeA) participate and regulate the stress response of the body when facing the stressor. Subsequently, the structures around the BLA were also found. It is located in the amygdala-like brain area deep in the temporal lobe of the brain, which is now the basolateral amygdala (BLA). The amygdala was first discovered by Burdach in the 19th century. The amygdala, another brain region, has attracted more and more researchers’ attention, because it is related to the pathophysiology of schizophrenia. Schizophrenia (SC) is a mental disorder that makes the brain decline, involving abnormalities in multiple brain regions, including the prefrontal cortex (PFC) and hippocampus. ![]() The abnormal volume and function of the amygdala play important roles in the disease process of SC, and are closely related to cognitive impairment. While the FALFF values of the bilateral amygdala were positively correlated with the PANSS score (r L=0.257, p = 0.026 r R=0.259, p = 0.026). (2) The volumes of the left amygdala were negatively correlated with the PANSS score (r L=-0.243, p = 0.039). Meanwhile, the left amygdala volume decreased (t=-3.675, p < 0.001), and the Fractional amplitude of low-frequency fluctuations (FALFF) values of bilateral amygdala increased (t L=3.916, p < 0.001 t R=3.131, p = 0.002). Compared with HC, the PANSS score of SC increased and the RBANS score decreased significantly. (1) There was no significant difference between SC and HC in age, gender and years of education. Pearson correlation analysis was used to compare the relationship between the structural and functional indicators of the amygdala and PANSS and RBANS. The Positive and Negative Syndrome Scale (PANSS) was used to assess the severity of the disease, and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) was used to assess cognitive function. The rsMRI technique and automatic segmentation tool were used to extract the volume and functional indicators of the SC’s amygdala. We collected 59 drug-naïve SCs and 46 healthy controls (HCs) from the Third People’s Hospital of Foshan. ![]() However, the mechanism is still unclear, so we explored the relationship between the amygdala resting state magnetic resonance imaging (rsMRI) signal and cognitive function, to provide a reference for the follow-up study. ![]() Recently studies had showed that the amygdala may take part in the cognitive impairment in schizophrenia (SC).
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